Crystal structure of 9-(4-bromobutyl)-9H-fluorene-9-carboxylic acid
نویسندگان
چکیده
The title compound, C18H17BrO2, is a key inter-mediate in the synthesis of lomitapide mesylate, a microsomal triglyceride transfer protein inhibitor. Its asymmetric unit contains two independent mol-ecules with slightly different conformations; the mean planes of the 4-bromo-butyl and carboxyl-ate groups in the two mol-ecules form dihedral angles of 24.54 (12) and 17.10 (18)°. In the crystal, carboxyl-ate groups are involved in O-H⋯O hydrogen bonding, which leads to the formation of two crystallographically independent centrosymmetric dimers. Weak inter-molecular C-H⋯O inter-actions further link these dimers into layers parallel to the bc plane.
منابع مشابه
9-Chloromethyl-9-[(9H-fluoren-9-yl)methyl]-9H-fluorene
In the title compound, C(28)H(21)Cl, the dihedral angle between the two fluorene ring systems is 71.97 (4)°. There is an intra-molecular C-H⋯Cl hydrogen bond. In the crystal structure, the centroid-to-centroid distance between stacked fluorene ring systems is ca 4.22 Å, which indicates that there are no π-π stacking inter-actions between them.
متن کامل9-(4-Bromobutyl)-9H-carbazole
In the title compound, C(16)H(16)BrN, the tricyclic carbazole system is essentially planar (r.m.s. deviation of all non-H atoms = 0.010 Å). The dihedral angle between the two outer carbazole rings is 1.1 (3)°. There are no directional inter-molecular contacts in the crystal packing.
متن کاملN-(9H-Fluoren-9-ylidene)-4-methylaniline
In the title compound, C(20)H(15)N, the fluorene unit is essentially planar [r.m.s. deviation 0.0334 Å] and the benzene ring bound to the imine N atom bears a methyl group which is nearly coplanar [dihedral angle 0.5 (1)°]. The dihedral angle between the substituent benzene ring and the 9H-fluoren-9-imine unit is 71.1 (3)°. Inter-molecular π-π inter-actions between the benzene rings of adjacent...
متن کامل9-(4-Bromobutyl)-9H-carbazole
In the title compound, C(16)H(16)BrN, the bromo-butyl group lies on one side of the carbazole ring plane and has a zigzag shape. The dihedral angle between the two benzene rings is 0.55°. In the crystal, mol-ecules are connected by van der Waals inter-actions.
متن کامل(9H-Fluoren-9-yl)(phenyl)phosphinic acid
The crystal structure of the title compound, C19H15O2P, features pairs of mol-ecules joined by O-H⋯O hydrogen bonds across crystallographic inversion centers. In addition, π-π inter-actions, with a centroid-centroid distance of 3.6273 (9) Å between the fluorene ring systems, connect the dimers into chains along [01-1]. The three rings make dihedral angles of 1.34 (9), 1.52 (10) and 1.51 (7)° wi...
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عنوان ژورنال:
دوره 70 شماره
صفحات -
تاریخ انتشار 2014